CidR and CcpA Synergistically Regulate Staphylococcus aureus cidABC Expression
نویسندگان
چکیده
منابع مشابه
Staphylococcus aureus CcpA affects biofilm formation.
Biofilm formation in Staphylococcus aureus under in vitro growth conditions is generally promoted by high concentrations of sugar and/or salts. The addition of glucose to routinely used complex growth media triggered biofilm formation in S. aureus strain SA113. Deletion of ccpA, coding for the catabolite control protein A (CcpA), which regulates gene expression in response to the carbon source,...
متن کاملAcetic acid induces expression of the Staphylococcus aureus cidABC and lrgAB murein hydrolase regulator operons.
The Staphylococcus aureus lrg and cid operons encode homologous proteins that regulate extracellular murein hydrolase activity and penicillin tolerance in a diametrically opposing manner. Although their specific regulatory functions remain unknown, it has been postulated that the functions of CidA and LrgA are analogous to those of bacteriophage holins and antiholins, respectively, and that the...
متن کاملStaphylococcus aureus CcpA affects virulence determinant production and antibiotic resistance.
Carbon catabolite protein A (CcpA) is known to function as a major regulator of gene expression in different gram-positive organisms. Deletion of the ccpA homologue (saCOL1786) in Staphylococcus aureus was found to affect growth, glucose metabolization, and transcription of selected virulence determinants. In liquid culture, deletion of CcpA decreased the growth rate and yield; however, the eff...
متن کاملCcpA Affects Infectivity of Staphylococcus aureus in a Hyperglycemic Environment
Many bacteria regulate the expression of virulence factors via carbon catabolite responsive elements. In Gram-positive bacteria, the predominant mediator of carbon catabolite repression is the catabolite control protein A (CcpA). Hyperglycemia is a widespread disorder that predisposes individuals to an array of symptoms and an increased risk of infections. In hyperglycemic individuals, the bact...
متن کاملCcpA mediates the catabolite repression of tst in Staphylococcus aureus.
Some clinical isolates of Staphylococcus aureus produce the superantigenic toxic shock syndrome toxin 1 (TSST-1), encoded by tst, located on pathogenicity islands. The expression of tst is complex and is influenced by environmental conditions such as pH, CO(2), and glucose. We identified a putative catabolite-responsive element (cre) in the promoter regions of all known tst genes, indicating th...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 2019
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.00371-19